My article was a mechanistic study with crystal structure and to support the claim there was biochemical analysis also. They rejected by saying "it lacks the kind of deep mechanistic insight into fundamental molecular or biochemical processes". In contrast to their view, the paper is all about atomic level mechanistic analysis with crystal structure and kinetic analysis. I really dont have any issue with the rejection as it do not fit the reputation or whatever. But I really felt cheated with the reason they gave. It clearly shows that they have not read the article at all.
