First review round: 4.9 weeks. Overall rating: 0 (very bad).
The reviewer looked not appropriate for reviewing the manuscript. The reviewers comment referred a lot to work with mice when the manuscript was exclusively work on humans. The difficulty in conducting the work in human samples, obtaining samples, and the advanced data analysis was not appreciated enough. The journal and reviewer did not find the manuscript mechanistic enough. False claims were made such as everything that we showed was previously knows which is not true for humans.