Journal info (provided by editor)

The editor of Cell Systems has not yet provided information for this page.

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Disciplines: Biology, Biotechnology

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Latest review

Outcome: Rejected (im.).

Motivation:
Since our paper was submitted during the holidays, the editorial decision was very quick. Our paper combined mathematical modeling with biochemical in vitro experiments and answered a long standing question in the field. Based on our model predictions and in vitro experiments, we also proposed to explore a new therapeutic approach (in preclinical studies) for patients with a lethal genetic mutation. The editor clearly read and understood the paper and deemed it to be interesting, the concepts to be novel and the in vitro data convincing. However, the paper would not be suitable for Cell Systems because we did not provide IN VIVO data which confirm our predictions. Given clear novelty, medical relevance and the interdisciplinary in silico/in vitro approach, I find this threshold quite high for a systems biology journal - particularly during Covid-19 times, which made it impossible for us to conduct further in vivo studies (due to limited operating capacity of our) and the necessary in vivo experiments are not trivial. Would I have in vivo data, I probably would have submitted the paper even higher. I generally like the journal and would submit again, but it might be worth considering before submitting that your experimental data might not be enough if the data are "only" in vitro.