Roughly one and a half months after submission I got 2 reviews. Reviewer #1 thought that the interpretation of data was incorrect (due to an incomplete understanding of the methodology which is partly my fault for not explaining). Reviewer #2 didn't question the correctness of the methodology, seemed to be aware of the developments in the field, but found the paper not groundbreaking enough for Adv. Sci. Tried appealing but in vain.
As both referees agreed that the work has scientific significance, the editor offered a transfer to 3 journals IF 3-4 which I rejected. I believe that the comments of referees were quite useful as correcting them would really improve the quality of the manuscript and it would get published in a journal with a similar IF like Adv. Sci. The editor was really nice and helpful and really tried finding a place for my work at Wiley.